An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves

Research output: Contribution to journalArticle

Abstract

To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

Details

Authors
Organisations
External organisations
  • Uppsala University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Biotechnology
Original languageEnglish
Article number031101
JournalBiomicrofluidics
Volume11
Issue number3
Publication statusPublished - 2017 May 1
Publication categoryResearch
Peer-reviewedYes

Related research output

Anna Fornell, 2018 Jun 5, Lund: Department of Biomedical Engineering, Lund university. 134 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)