An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients

Research output: Contribution to journalArticle

Abstract

In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.

Details

Authors
  • Hareth Nahi
  • Hans Hägglund
  • Thomas Ahlgren
  • Per Bernell
  • Mats Hardling
  • Karin Karlsson
  • Vladimir Lj Lazarevic
  • Mats Linderholm
  • Bengt Smedmyr
  • Maria Aström
  • Helene Hallböök
Organisations
External organisations
  • Skåne University Hospital
  • Norrland University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • Adolescent, Adult, Aged, Burkitt Lymphoma, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 22, Chromosomes, Human, Pair 9, Genetic Markers, Humans, Karyotyping, Leukocyte Count, Middle Aged, Prognosis, Sequence Deletion, Survival Analysis, Translocation, Genetic, World Health Organization
Original languageEnglish
Pages (from-to)1734-8
Number of pages5
JournalHaematologica
Volume93
Issue number11
Publication statusPublished - 2008 Nov
Publication categoryResearch
Peer-reviewedYes