An open and shut case

Research output: Contribution to journalLetter

Abstract

A powerful new NMR technique applied to the ubiquitous Ca2+ sensor, calmodulin, reveals significant conformational flexibility within each globular domain, which contributes to its ability to bind a wide range of targets. These measurements of residual dipolar couplings between nuclear spins demonstrate a fast and accurate method for pinpointing structural features that cannot be delineated reliably by traditional NOE analysis.

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Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry
Original languageEnglish
Pages (from-to)910-912
JournalNature Structural Biology
Volume8
Issue number11
Publication statusPublished - 2001
Publication categoryResearch
Peer-reviewedYes