An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.

Research output: Contribution to journalArticle

Abstract

Individuals carrying pathogenic mutations in BRCA1/2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals from different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. Here we test the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers.

Details

Authors
  • Sophie Blein
  • Claire Bardel
  • Vincent Danjean
  • Lesley McGuffog
  • Sue Healey
  • Daniel Barrowdale
  • Andrew Lee
  • Joe Dennis
  • Karoline B Kuchenbaecker
  • Penny Soucy
  • Mary Beth Terry
  • Wendy K Chung
  • David E Goldgar
  • Saundra S Buys
  • Ramunas Janavicius
  • Laima Tihomirova
  • Nadine Tung
  • Cecilia M Dorfling
  • Elizabeth J van Rensburg
  • Susan L Neuhausen
  • Yuan Chun Ding
  • Anne-Marie Gerdes
  • Bent Ejlertsen
  • Finn C Nielsen
  • Thomas Vo Hansen
  • Ana Osorio
  • Javier Benitez
  • Raquel Andrés-Conejero
  • Ena Segota
  • Jeffrey N Weitzel
  • Margo Thelander
  • Paolo Peterlongo
  • Paolo Radice
  • Valeria Pensotti
  • Riccardo Dolcetti
  • Bernardo Bonanni
  • Bernard Peissel
  • Daniela Zaffaroni
  • Giulietta Scuvera
  • Siranoush Manoukian
  • Liliana Varesco
  • Gabriele L Capone
  • Laura Papi
  • Laura Ottini
  • Drakoulis Yannoukakos
  • Irene Konstantopoulou
  • Judy Garber
  • Ute Hamann
  • Alan Donaldson
  • Angela Brady
  • Carole Brewer
  • Claire Foo
  • D Gareth Evans
  • Debra Frost
  • Diana Eccles
  • Fiona Douglas
  • Jackie Cook
  • Julian Adlard
  • Julian Barwell
  • Lisa Walker
  • Louise Izatt
  • Lucy E Side
  • M John Kennedy
  • Marc Tischkowitz
  • Mark T Rogers
  • Mary E Porteous
  • Patrick J Morrison
  • Radka Platte
  • Ros Eeles
  • Rosemarie Davidson
  • Shirley Hodgson
  • Trevor Cole
  • Andrew K Godwin
  • Claudine Isaacs
  • Kathleen Claes
  • Kim De Leeneer
  • Alfons Meindl
  • Andrea Gehrig
  • Barbara Wappenschmidt
  • Christian Sutter
  • Christoph Engel
  • Dieter Niederacher
  • Doris Steinemann
  • Hansjoerg Plendl
  • Karin Kast
  • Kerstin Rhiem
  • Nina Ditsch
  • Norbert Arnold
  • Raymonda Varon-Mateeva
  • Rita K Schmutzler
  • Sabine Preisler-Adams
  • Nadja Bogdanova Markov
  • Shan Wang-Gohrke
  • Antoine de Pauw
  • Cédrick Lefol
  • Christine Lasset
  • Dominique Leroux
  • Etienne Rouleau
  • Francesca Damiola
  • Hélène Dreyfus
  • Laure Barjhoux
  • Lisa Golmard
  • Nancy Uhrhammer
  • Valérie Bonadona
  • Valérie Sornin
  • Yves-Jean Bignon
  • Jonathan Carter
  • Linda Van Le
  • Marion Piedmonte
  • Paul A DiSilvestro
  • Miguel de la Hoya
  • Trinidad Caldes
  • Heli Nevanlinna
  • Kristiina Aittomäki
  • Agnes Jager
  • Ans Mw van den Ouweland
  • Carolien M Kets
  • Cora M Aalfs
  • Flora E van Leeuwen
  • Frans Bl Hogervorst
  • Hanne Ej Meijers-Heijboer
  • Jan C Oosterwijk
  • Kees Ep van Roozendaal
  • Matti A Rookus
  • Peter Devilee
  • Rob B van der Luijt
  • Edith Olah
  • Orland Diez
  • Alex Teulé
  • Conxi Lazaro
  • Ignacio Blanco
  • Jesús Del Valle
  • Anna Jakubowska
  • Grzegorz Sukiennicki
  • Jacek Gronwald
  • Jan Lubinski
  • Katarzyna Durda
  • Katarzyna Jaworska-Bieniek
  • Bjarni A Agnarsson
  • Christine Maugard
  • Alberto Amadori
  • Marco Montagna
  • Manuel R Teixeira
  • Amanda B Spurdle
  • William Foulkes
  • Curtis Olswold
  • Noralane Lindor
  • Vernon S Pankratz
  • Csilla I Szabo
  • Anne Lincoln
  • Lauren Jacobs
  • Marina Corines
  • Mark Robson
  • Joseph Vijai
  • Andreas Berger
  • Anneliese Fink-Retter
  • Christian F Singer
  • Christine Rappaport
  • Daphne Geschwantler Kaulich
  • Georg Pfeiler
  • Muy-Kheng Tea
  • Mark H Greene
  • Phuong L Mai
  • Gad Rennert
  • Evgeny N Imyanitov
  • Anna Marie Mulligan
  • Gord Glendon
  • Irene L Andrulis
  • Sandrine Tchatchou
  • Amanda Ewart Toland
  • Inge Sokilde Pedersen
  • Mads Thomassen
  • Torben A Kruse
  • Uffe Birk Jensen
  • Maria A Caligo
  • Eitan Friedman
  • Jamal Zidan
  • Yael Laitman
  • Annika Lindblom
  • Beatrice Melin
  • Brita Arver
  • Richard Rosenquist
  • Olufunmilayo I Olopade
  • Robert L Nussbaum
  • Susan J Ramus
  • Katherine L Nathanson
  • Susan M Domchek
  • Timothy R Rebbeck
  • Banu K Arun
  • Gillian Mitchell
  • Beth Y Karlan
  • Jenny Lester
  • Sandra Orsulic
  • Dominique Stoppa-Lyonnet
  • Gilles Thomas
  • Jacques Simard
  • Fergus J Couch
  • Kenneth Offit
  • Douglas F Easton
  • Georgia Chenevix-Trench
  • Antonis C Antoniou
  • Sylvie Mazoyer
  • Catherine M Phelan
  • Olga M Sinilnikova
  • David G Cox
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Article number61
JournalBreast Cancer Research
Volume17
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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