An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

Research output: Contribution to journalReview article

Abstract

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-sensitive assays have enabled the levels of pathological proteins to be measured in blood samples, but research has been predominantly focused on Alzheimer disease (AD). Nonetheless, proteins that were identified as potential blood-based biomarkers for AD, for example, amyloid-β, tau, phosphorylated tau and neurofilament light chain, are likely to be relevant to other neurodegenerative disorders that involve similar pathological processes and could also be useful for the differential diagnosis of clinical symptoms. This Review outlines the neuropathological, clinical, molecular imaging and cerebrospinal fluid features of the most common neurodegenerative disorders outside the AD continuum and gives an overview of the current status of blood-based biomarkers for these disorders.

Details

Authors
  • Nicholas J. Ashton
  • Abdul Hye
  • Anto P. Rajkumar
  • Antoine Leuzy
  • Stuart Snowden
  • Marc Suárez-Calvet
  • Thomas K. Karikari
  • Michael Schöll
  • Renaud La Joie
  • Gil D. Rabinovici
  • Kina Höglund
  • Clive Ballard
  • Tibor Hortobágyi
  • Per Svenningsson
  • Kaj Blennow
  • Henrik Zetterberg
  • Dag Aarsland
Organisations
External organisations
  • King's College London
  • University of Nottingham
  • University of Cambridge
  • Hospital del Mar Medical Research Institute
  • University College London
  • University of California, San Francisco
  • Karolinska Institutet
  • University of Exeter
  • University of Debrecen
  • Sahlgrenska University Hospital
  • University of Gothenburg
  • Stavanger University Hospital
  • South London and Maudsley NHS Foundation Trust
  • Pasqual Maragall Foundation for Research on Alzheimer
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)265-284
Number of pages20
JournalNature Reviews Neurology
Volume16
Issue number5
Publication statusPublished - 2020
Publication categoryResearch
Peer-reviewedYes