Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Research output: Contribution to journalArticle

Standard

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. / Beecham, Ashley H.; Patsopoulos, Nikolaos A.; Xifara, Dionysia K.; Davis, Mary F.; Kemppinen, Anu; Cotsapas, Chris; Shah, Tejas S.; Spencer, Chris; Booth, David; Goris, An; Oturai, Annette; Saarela, Janna; Fontaine, Bertrand; Hemmer, Bernhard; Martin, Claes; Zipp, Frauke; D'Alfonso, Sandra; Martinelli-Boneschi, Filippo; Taylor, Bruce; Harbo, Hanne F.; Kockum, Ingrid; Hillert, Jan; Olsson, Tomas; Ban, Maria; Oksenberg, Jorge R.; Hintzen, Rogier; Barcellos, Lisa F.; Agliardi, Cristina; Alfredsson, Lars; Alizadeh, Mehdi; Anderson, Carl; Andrews, Robert; Sondergaard, Helle Bach; Baker, Amie; Band, Gavin; Baranzini, Sergio E.; Barizzone, Nadia; Barrett, Jeffrey; Bellenguez, Celine; Bergamaschi, Laura; Bernardinelli, Luisa; Berthele, Achim; Biberacher, Viola; Binder, Thomas M. C.; Blackburn, Hannah; Bomfim, Izaura L.; Brambilla, Paola; Broadley, Simon; Brochet, Bruno; Brundin, Lou; Buck, Dorothea; Butzkueven, Helmut; Caillier, Stacy J.; Camu, William; Carpentier, Wassila; Cavalla, Paola; Celius, Elisabeth G.; Coman, Irene; Comi, Giancarlo; Corrado, Lucia; Cosemans, Leentje; Cournu-Rebeix, Isabelle; Cree, Bruce A. C.; Cusi, Daniele; Damotte, Vincent; Defer, Gilles; Delgado, Silvia R.; Deloukas, Panos; di Sapio, Alessia; Dilthey, Alexander T.; Donnelly, Peter; Dubois, Benedicte; Duddy, Martin; Edkins, Sarah; Elovaara, Irina; Esposito, Federica; Evangelou, Nikos; Fiddes, Barnaby; Field, Judith; Franke, Andre; Freeman, Colin; Frohlich, Irene Y.; Galimberti, Daniela; Gieger, Christian; Gourraud, Pierre-Antoine; Graetz, Christiane; Graham, Andrew; Grummel, Verena; Guaschino, Clara; Hadjixenofontos, Athena; Hakonarson, Hakon; Halfpenny, Christopher; Hall, Gillian; Hall, Per; Hamsten, Anders; Harley, James; Harrower, Timothy; Hawkins, Clive; Hellenthal, Garrett; Hillier, Charles; Hobart, Jeremy; Hoshi, Muni; Hunt, Sarah E.; Jagodic, Maja; Jelcic, Ilijas; Jochim, Angela; Kendall, Brian; Kermode, Allan; Kilpatrick, Trevor; Koivisto, Keijo; Konidari, Ioanna; Korn, Thomas; Kronsbein, Helena; Langford, Cordelia; Larsson, Malin; Lathrop, Mark; Lebrun-Frenay, Christine; Lechner-Scott, Jeannette; Lee, Michelle H.; Leone, Maurizio A.; Leppa, Virpi; Liberatore, Giuseppe; Lie, Benedicte A.; Lill, Christina M.; Linden, Magdalena; Link, Jenny; Luessi, Felix; Lycke, Jan; Macciardi, Fabio; Mannisto, Satu; Manrique, Clara P.; Martin, Roland; Martinelli, Vittorio; Mason, Deborah; Mazibrada, Gordon; McCabe, Cristin; Mero, Inger-Lise; Mescheriakova, Julia; Moutsianas, Loukas; Myhr, Kjell-Morten; Nagels, Guy; Nicholas, Richard; Nilsson, Petra; Piehl, Fredrik; Pirinen, Matti; Price, Sian E.; Quach, Hong; Reunanen, Mauri; Robberecht, Wim; Robertson, Neil P.; Rodegher, Mariaemma; Rog, David; Salvetti, Marco; Schnetz-Boutaud, Nathalie C.; Sellebjerg, Finn; Selter, Rebecca C.; Schaefer, Catherine; Shaunak, Sandip; Shen, Ling; Shields, Simon; Siffrin, Volker; Slee, Mark; Sorensen, Per Soelberg; Sorosina, Melissa; Sospedra, Mireia; Spurkland, Anne; Strange, Amy; Sundqvist, Emilie; Thijs, Vincent; Thorpe, John; Ticca, Anna; Tienari, Pentti; van Duijn, Cornelia; Visser, Elizabeth M.; Vucic, Steve; Westerlind, Helga; Wiley, James S.; Wilkins, Alastair; Wilson, James F.; Winkelmann, Juliane; Zajicek, John; Zindler, Eva; Haines, Jonathan L.; Pericak-Vance, Margaret A.; Ivinson, Adrian J.; Stewart, Graeme; Hafler, David; Hauser, Stephen L.; Compston, Alastair; McVean, Gil; De Jager, Philip; Sawcer, Stephen J.; McCauley, Jacob L.

In: Nature Genetics, Vol. 45, No. 11, 2013, p. 1353.

Research output: Contribution to journalArticle

Harvard

Beecham, AH, Patsopoulos, NA, Xifara, DK, Davis, MF, Kemppinen, A, Cotsapas, C, Shah, TS, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, HF, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, JR, Hintzen, R, Barcellos, LF, Agliardi, C, Alfredsson, L, Alizadeh, M, Anderson, C, Andrews, R, Sondergaard, HB, Baker, A, Band, G, Baranzini, SE, Barizzone, N, Barrett, J, Bellenguez, C, Bergamaschi, L, Bernardinelli, L, Berthele, A, Biberacher, V, Binder, TMC, Blackburn, H, Bomfim, IL, Brambilla, P, Broadley, S, Brochet, B, Brundin, L, Buck, D, Butzkueven, H, Caillier, SJ, Camu, W, Carpentier, W, Cavalla, P, Celius, EG, Coman, I, Comi, G, Corrado, L, Cosemans, L, Cournu-Rebeix, I, Cree, BAC, Cusi, D, Damotte, V, Defer, G, Delgado, SR, Deloukas, P, di Sapio, A, Dilthey, AT, Donnelly, P, Dubois, B, Duddy, M, Edkins, S, Elovaara, I, Esposito, F, Evangelou, N, Fiddes, B, Field, J, Franke, A, Freeman, C, Frohlich, IY, Galimberti, D, Gieger, C, Gourraud, P-A, Graetz, C, Graham, A, Grummel, V, Guaschino, C, Hadjixenofontos, A, Hakonarson, H, Halfpenny, C, Hall, G, Hall, P, Hamsten, A, Harley, J, Harrower, T, Hawkins, C, Hellenthal, G, Hillier, C, Hobart, J, Hoshi, M, Hunt, SE, Jagodic, M, Jelcic, I, Jochim, A, Kendall, B, Kermode, A, Kilpatrick, T, Koivisto, K, Konidari, I, Korn, T, Kronsbein, H, Langford, C, Larsson, M, Lathrop, M, Lebrun-Frenay, C, Lechner-Scott, J, Lee, MH, Leone, MA, Leppa, V, Liberatore, G, Lie, BA, Lill, CM, Linden, M, Link, J, Luessi, F, Lycke, J, Macciardi, F, Mannisto, S, Manrique, CP, Martin, R, Martinelli, V, Mason, D, Mazibrada, G, McCabe, C, Mero, I-L, Mescheriakova, J, Moutsianas, L, Myhr, K-M, Nagels, G, Nicholas, R, Nilsson, P, Piehl, F, Pirinen, M, Price, SE, Quach, H, Reunanen, M, Robberecht, W, Robertson, NP, Rodegher, M, Rog, D, Salvetti, M, Schnetz-Boutaud, NC, Sellebjerg, F, Selter, RC, Schaefer, C, Shaunak, S, Shen, L, Shields, S, Siffrin, V, Slee, M, Sorensen, PS, Sorosina, M, Sospedra, M, Spurkland, A, Strange, A, Sundqvist, E, Thijs, V, Thorpe, J, Ticca, A, Tienari, P, van Duijn, C, Visser, EM, Vucic, S, Westerlind, H, Wiley, JS, Wilkins, A, Wilson, JF, Winkelmann, J, Zajicek, J, Zindler, E, Haines, JL, Pericak-Vance, MA, Ivinson, AJ, Stewart, G, Hafler, D, Hauser, SL, Compston, A, McVean, G, De Jager, P, Sawcer, SJ & McCauley, JL 2013, 'Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis', Nature Genetics, vol. 45, no. 11, pp. 1353. https://doi.org/10.1038/ng.2770

APA

Beecham, A. H., Patsopoulos, N. A., Xifara, D. K., Davis, M. F., Kemppinen, A., Cotsapas, C., Shah, T. S., Spencer, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., Hemmer, B., Martin, C., Zipp, F., D'Alfonso, S., Martinelli-Boneschi, F., Taylor, B., ... McCauley, J. L. (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics, 45(11), 1353. https://doi.org/10.1038/ng.2770

CBE

Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF, Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Sondergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TMC, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BAC, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud P-A, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelcic I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppa V, Liberatore G, Lie BA, Lill CM, Linden M, Link J, Luessi F, Lycke J, Macciardi F, Mannisto S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero I-L, Mescheriakova J, Moutsianas L, Myhr K-M, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL. 2013. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics. 45(11):1353. https://doi.org/10.1038/ng.2770

MLA

Vancouver

Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics. 2013;45(11):1353. https://doi.org/10.1038/ng.2770

Author

Beecham, Ashley H. ; Patsopoulos, Nikolaos A. ; Xifara, Dionysia K. ; Davis, Mary F. ; Kemppinen, Anu ; Cotsapas, Chris ; Shah, Tejas S. ; Spencer, Chris ; Booth, David ; Goris, An ; Oturai, Annette ; Saarela, Janna ; Fontaine, Bertrand ; Hemmer, Bernhard ; Martin, Claes ; Zipp, Frauke ; D'Alfonso, Sandra ; Martinelli-Boneschi, Filippo ; Taylor, Bruce ; Harbo, Hanne F. ; Kockum, Ingrid ; Hillert, Jan ; Olsson, Tomas ; Ban, Maria ; Oksenberg, Jorge R. ; Hintzen, Rogier ; Barcellos, Lisa F. ; Agliardi, Cristina ; Alfredsson, Lars ; Alizadeh, Mehdi ; Anderson, Carl ; Andrews, Robert ; Sondergaard, Helle Bach ; Baker, Amie ; Band, Gavin ; Baranzini, Sergio E. ; Barizzone, Nadia ; Barrett, Jeffrey ; Bellenguez, Celine ; Bergamaschi, Laura ; Bernardinelli, Luisa ; Berthele, Achim ; Biberacher, Viola ; Binder, Thomas M. C. ; Blackburn, Hannah ; Bomfim, Izaura L. ; Brambilla, Paola ; Broadley, Simon ; Brochet, Bruno ; Brundin, Lou ; Buck, Dorothea ; Butzkueven, Helmut ; Caillier, Stacy J. ; Camu, William ; Carpentier, Wassila ; Cavalla, Paola ; Celius, Elisabeth G. ; Coman, Irene ; Comi, Giancarlo ; Corrado, Lucia ; Cosemans, Leentje ; Cournu-Rebeix, Isabelle ; Cree, Bruce A. C. ; Cusi, Daniele ; Damotte, Vincent ; Defer, Gilles ; Delgado, Silvia R. ; Deloukas, Panos ; di Sapio, Alessia ; Dilthey, Alexander T. ; Donnelly, Peter ; Dubois, Benedicte ; Duddy, Martin ; Edkins, Sarah ; Elovaara, Irina ; Esposito, Federica ; Evangelou, Nikos ; Fiddes, Barnaby ; Field, Judith ; Franke, Andre ; Freeman, Colin ; Frohlich, Irene Y. ; Galimberti, Daniela ; Gieger, Christian ; Gourraud, Pierre-Antoine ; Graetz, Christiane ; Graham, Andrew ; Grummel, Verena ; Guaschino, Clara ; Hadjixenofontos, Athena ; Hakonarson, Hakon ; Halfpenny, Christopher ; Hall, Gillian ; Hall, Per ; Hamsten, Anders ; Harley, James ; Harrower, Timothy ; Hawkins, Clive ; Hellenthal, Garrett ; Hillier, Charles ; Hobart, Jeremy ; Hoshi, Muni ; Hunt, Sarah E. ; Jagodic, Maja ; Jelcic, Ilijas ; Jochim, Angela ; Kendall, Brian ; Kermode, Allan ; Kilpatrick, Trevor ; Koivisto, Keijo ; Konidari, Ioanna ; Korn, Thomas ; Kronsbein, Helena ; Langford, Cordelia ; Larsson, Malin ; Lathrop, Mark ; Lebrun-Frenay, Christine ; Lechner-Scott, Jeannette ; Lee, Michelle H. ; Leone, Maurizio A. ; Leppa, Virpi ; Liberatore, Giuseppe ; Lie, Benedicte A. ; Lill, Christina M. ; Linden, Magdalena ; Link, Jenny ; Luessi, Felix ; Lycke, Jan ; Macciardi, Fabio ; Mannisto, Satu ; Manrique, Clara P. ; Martin, Roland ; Martinelli, Vittorio ; Mason, Deborah ; Mazibrada, Gordon ; McCabe, Cristin ; Mero, Inger-Lise ; Mescheriakova, Julia ; Moutsianas, Loukas ; Myhr, Kjell-Morten ; Nagels, Guy ; Nicholas, Richard ; Nilsson, Petra ; Piehl, Fredrik ; Pirinen, Matti ; Price, Sian E. ; Quach, Hong ; Reunanen, Mauri ; Robberecht, Wim ; Robertson, Neil P. ; Rodegher, Mariaemma ; Rog, David ; Salvetti, Marco ; Schnetz-Boutaud, Nathalie C. ; Sellebjerg, Finn ; Selter, Rebecca C. ; Schaefer, Catherine ; Shaunak, Sandip ; Shen, Ling ; Shields, Simon ; Siffrin, Volker ; Slee, Mark ; Sorensen, Per Soelberg ; Sorosina, Melissa ; Sospedra, Mireia ; Spurkland, Anne ; Strange, Amy ; Sundqvist, Emilie ; Thijs, Vincent ; Thorpe, John ; Ticca, Anna ; Tienari, Pentti ; van Duijn, Cornelia ; Visser, Elizabeth M. ; Vucic, Steve ; Westerlind, Helga ; Wiley, James S. ; Wilkins, Alastair ; Wilson, James F. ; Winkelmann, Juliane ; Zajicek, John ; Zindler, Eva ; Haines, Jonathan L. ; Pericak-Vance, Margaret A. ; Ivinson, Adrian J. ; Stewart, Graeme ; Hafler, David ; Hauser, Stephen L. ; Compston, Alastair ; McVean, Gil ; De Jager, Philip ; Sawcer, Stephen J. ; McCauley, Jacob L. / Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. In: Nature Genetics. 2013 ; Vol. 45, No. 11. pp. 1353.

RIS

TY - JOUR

T1 - Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

AU - Beecham, Ashley H.

AU - Patsopoulos, Nikolaos A.

AU - Xifara, Dionysia K.

AU - Davis, Mary F.

AU - Kemppinen, Anu

AU - Cotsapas, Chris

AU - Shah, Tejas S.

AU - Spencer, Chris

AU - Booth, David

AU - Goris, An

AU - Oturai, Annette

AU - Saarela, Janna

AU - Fontaine, Bertrand

AU - Hemmer, Bernhard

AU - Martin, Claes

AU - Zipp, Frauke

AU - D'Alfonso, Sandra

AU - Martinelli-Boneschi, Filippo

AU - Taylor, Bruce

AU - Harbo, Hanne F.

AU - Kockum, Ingrid

AU - Hillert, Jan

AU - Olsson, Tomas

AU - Ban, Maria

AU - Oksenberg, Jorge R.

AU - Hintzen, Rogier

AU - Barcellos, Lisa F.

AU - Agliardi, Cristina

AU - Alfredsson, Lars

AU - Alizadeh, Mehdi

AU - Anderson, Carl

AU - Andrews, Robert

AU - Sondergaard, Helle Bach

AU - Baker, Amie

AU - Band, Gavin

AU - Baranzini, Sergio E.

AU - Barizzone, Nadia

AU - Barrett, Jeffrey

AU - Bellenguez, Celine

AU - Bergamaschi, Laura

AU - Bernardinelli, Luisa

AU - Berthele, Achim

AU - Biberacher, Viola

AU - Binder, Thomas M. C.

AU - Blackburn, Hannah

AU - Bomfim, Izaura L.

AU - Brambilla, Paola

AU - Broadley, Simon

AU - Brochet, Bruno

AU - Brundin, Lou

AU - Buck, Dorothea

AU - Butzkueven, Helmut

AU - Caillier, Stacy J.

AU - Camu, William

AU - Carpentier, Wassila

AU - Cavalla, Paola

AU - Celius, Elisabeth G.

AU - Coman, Irene

AU - Comi, Giancarlo

AU - Corrado, Lucia

AU - Cosemans, Leentje

AU - Cournu-Rebeix, Isabelle

AU - Cree, Bruce A. C.

AU - Cusi, Daniele

AU - Damotte, Vincent

AU - Defer, Gilles

AU - Delgado, Silvia R.

AU - Deloukas, Panos

AU - di Sapio, Alessia

AU - Dilthey, Alexander T.

AU - Donnelly, Peter

AU - Dubois, Benedicte

AU - Duddy, Martin

AU - Edkins, Sarah

AU - Elovaara, Irina

AU - Esposito, Federica

AU - Evangelou, Nikos

AU - Fiddes, Barnaby

AU - Field, Judith

AU - Franke, Andre

AU - Freeman, Colin

AU - Frohlich, Irene Y.

AU - Galimberti, Daniela

AU - Gieger, Christian

AU - Gourraud, Pierre-Antoine

AU - Graetz, Christiane

AU - Graham, Andrew

AU - Grummel, Verena

AU - Guaschino, Clara

AU - Hadjixenofontos, Athena

AU - Hakonarson, Hakon

AU - Halfpenny, Christopher

AU - Hall, Gillian

AU - Hall, Per

AU - Hamsten, Anders

AU - Harley, James

AU - Harrower, Timothy

AU - Hawkins, Clive

AU - Hellenthal, Garrett

AU - Hillier, Charles

AU - Hobart, Jeremy

AU - Hoshi, Muni

AU - Hunt, Sarah E.

AU - Jagodic, Maja

AU - Jelcic, Ilijas

AU - Jochim, Angela

AU - Kendall, Brian

AU - Kermode, Allan

AU - Kilpatrick, Trevor

AU - Koivisto, Keijo

AU - Konidari, Ioanna

AU - Korn, Thomas

AU - Kronsbein, Helena

AU - Langford, Cordelia

AU - Larsson, Malin

AU - Lathrop, Mark

AU - Lebrun-Frenay, Christine

AU - Lechner-Scott, Jeannette

AU - Lee, Michelle H.

AU - Leone, Maurizio A.

AU - Leppa, Virpi

AU - Liberatore, Giuseppe

AU - Lie, Benedicte A.

AU - Lill, Christina M.

AU - Linden, Magdalena

AU - Link, Jenny

AU - Luessi, Felix

AU - Lycke, Jan

AU - Macciardi, Fabio

AU - Mannisto, Satu

AU - Manrique, Clara P.

AU - Martin, Roland

AU - Martinelli, Vittorio

AU - Mason, Deborah

AU - Mazibrada, Gordon

AU - McCabe, Cristin

AU - Mero, Inger-Lise

AU - Mescheriakova, Julia

AU - Moutsianas, Loukas

AU - Myhr, Kjell-Morten

AU - Nagels, Guy

AU - Nicholas, Richard

AU - Nilsson, Petra

AU - Piehl, Fredrik

AU - Pirinen, Matti

AU - Price, Sian E.

AU - Quach, Hong

AU - Reunanen, Mauri

AU - Robberecht, Wim

AU - Robertson, Neil P.

AU - Rodegher, Mariaemma

AU - Rog, David

AU - Salvetti, Marco

AU - Schnetz-Boutaud, Nathalie C.

AU - Sellebjerg, Finn

AU - Selter, Rebecca C.

AU - Schaefer, Catherine

AU - Shaunak, Sandip

AU - Shen, Ling

AU - Shields, Simon

AU - Siffrin, Volker

AU - Slee, Mark

AU - Sorensen, Per Soelberg

AU - Sorosina, Melissa

AU - Sospedra, Mireia

AU - Spurkland, Anne

AU - Strange, Amy

AU - Sundqvist, Emilie

AU - Thijs, Vincent

AU - Thorpe, John

AU - Ticca, Anna

AU - Tienari, Pentti

AU - van Duijn, Cornelia

AU - Visser, Elizabeth M.

AU - Vucic, Steve

AU - Westerlind, Helga

AU - Wiley, James S.

AU - Wilkins, Alastair

AU - Wilson, James F.

AU - Winkelmann, Juliane

AU - Zajicek, John

AU - Zindler, Eva

AU - Haines, Jonathan L.

AU - Pericak-Vance, Margaret A.

AU - Ivinson, Adrian J.

AU - Stewart, Graeme

AU - Hafler, David

AU - Hauser, Stephen L.

AU - Compston, Alastair

AU - McVean, Gil

AU - De Jager, Philip

AU - Sawcer, Stephen J.

AU - McCauley, Jacob L.

PY - 2013

Y1 - 2013

N2 - Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 x 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 x 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.

AB - Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 x 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 x 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.

U2 - 10.1038/ng.2770

DO - 10.1038/ng.2770

M3 - Article

C2 - 24076602

VL - 45

SP - 1353

JO - Nature Genetics

JF - Nature Genetics

SN - 1546-1718

IS - 11

ER -