Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis

Research output: Contribution to journalArticle

Abstract

Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.

Details

Authors
  • A Lopez de Lapuente
  • I Alloza
  • R Goertsches
  • U K Zettl
  • E Urcelay
  • R Arroyo
  • M Comabella
  • X Montalban
  • A Antigüedad
  • K Vandenbroeck
External organisations
  • University of the Basque Country
Research areas and keywords

Keywords

  • Adult, Case-Control Studies, Cohort Studies, Female, Genetic Loci/genetics, Genetic Predisposition to Disease/epidemiology, Humans, Male, Middle Aged, Multiple Sclerosis/epidemiology, Polymorphism, Genetic/genetics, Receptors, Cytokine/genetics, Risk Factors, Young Adult
Original languageEnglish
Pages (from-to)98-101
JournalJournal of Neuroimmunology
Volume245
Issue number1-2
Publication statusPublished - 2012 Apr
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes

Bibliographic note

Copyright © 2012 Elsevier B.V. All rights reserved.