Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington's Disease.

Research output: Contribution to journalArticle

Abstract

In addition to classical neurological symptoms, Huntington's disease (HD) is complicated by peripheral pathology and both the mutant gene and the protein are found in cells and tissues throughout the body. Despite the adipose tissue gene expression alterations described in HD mouse models, adipose tissue and its gene expression signature have not been previously explored in human HD.

Details

Authors
  • Andy McCourt
  • Jennifer Parker
  • Edina Silajdzic
  • Salman Haider
  • Huma Sethi
  • Sarah J Tabrizi
  • Thomas T Warner
  • Maria Björkqvist
Organisations
External organisations
  • University College London
  • National Hospital for Neurology and Neurosurgery
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)371-382
JournalJournal of Huntington's disease
Volume4
Issue number4
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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Related research output

Mccourt, A., 2016, Lund: Lund University: Faculty of Medicine. 80 p.

Research output: ThesisDoctoral Thesis (compilation)

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