Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men

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Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men. / Vandenput, Liesbeth; Mellstrom, Dan; Lorentzon, Mattias; Swanson, Charlotte; Karlsson, Magnus; Brandberg, John; Lonn, Lars; Orwoll, Eric; Smith, Ulf; Labrie, Fernand; Ljunggren, Osten; Tivesten, Asa; Ohlsson, Claes.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 11, 2007, p. 4130-4137.

Research output: Contribution to journalArticle

Harvard

Vandenput, L, Mellstrom, D, Lorentzon, M, Swanson, C, Karlsson, M, Brandberg, J, Lonn, L, Orwoll, E, Smith, U, Labrie, F, Ljunggren, O, Tivesten, A & Ohlsson, C 2007, 'Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men', Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 11, pp. 4130-4137. https://doi.org/10.1210/jc.2007-0252

APA

Vandenput, L., Mellstrom, D., Lorentzon, M., Swanson, C., Karlsson, M., Brandberg, J., Lonn, L., Orwoll, E., Smith, U., Labrie, F., Ljunggren, O., Tivesten, A., & Ohlsson, C. (2007). Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men. Journal of Clinical Endocrinology and Metabolism, 92(11), 4130-4137. https://doi.org/10.1210/jc.2007-0252

CBE

Vandenput L, Mellstrom D, Lorentzon M, Swanson C, Karlsson M, Brandberg J, Lonn L, Orwoll E, Smith U, Labrie F, Ljunggren O, Tivesten A, Ohlsson C. 2007. Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men. Journal of Clinical Endocrinology and Metabolism. 92(11):4130-4137. https://doi.org/10.1210/jc.2007-0252

MLA

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Author

Vandenput, Liesbeth ; Mellstrom, Dan ; Lorentzon, Mattias ; Swanson, Charlotte ; Karlsson, Magnus ; Brandberg, John ; Lonn, Lars ; Orwoll, Eric ; Smith, Ulf ; Labrie, Fernand ; Ljunggren, Osten ; Tivesten, Asa ; Ohlsson, Claes. / Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men. In: Journal of Clinical Endocrinology and Metabolism. 2007 ; Vol. 92, No. 11. pp. 4130-4137.

RIS

TY - JOUR

T1 - Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men

AU - Vandenput, Liesbeth

AU - Mellstrom, Dan

AU - Lorentzon, Mattias

AU - Swanson, Charlotte

AU - Karlsson, Magnus

AU - Brandberg, John

AU - Lonn, Lars

AU - Orwoll, Eric

AU - Smith, Ulf

AU - Labrie, Fernand

AU - Ljunggren, Osten

AU - Tivesten, Asa

AU - Ohlsson, Claes

PY - 2007

Y1 - 2007

N2 - Context: Androgens are associated with metabolic risk factors in men. However, the independent impact of androgens and androgen metabolites on metabolic risk factors in men is unclear. Objective: Our objective was to determine the predictive value of serum levels of androgens and glucuronidated androgen metabolites for metabolic risk factors. Design and Study Subjects: We conducted a population-based study of two Swedish cohorts (1068 young adult and 1001 elderly men). Main Outcome Measures: We measured correlation of serum dihydrotestosterone (DHT), testosterone (T), and glucuronidated androgen metabolites with fat mass, fat distribution, serum lipids, and insulin resistance. Results: Both DHT and T were negatively associated with different measures of fat mass in both cohorts (P < 0.001). Further statistical analysis indicated that DHT, but not T, was independently negatively associated with different measures of fat mass and insulin resistance (P < 0.001). The glucuronidated androgen metabolite androstane-3alpha,17beta-diol-17glucuronide (17G) was independently positively associated with fat mass (P < 0.001). Most importantly, the 17G to DHT ratio was strongly correlated, not only with fat mass but also with central fat distribution, intrahepatic fat, disturbed lipid profile, insulin resistance, and diabetes, explaining a substantial part of the total variance in total body fat (12% in young adult men, 15% in elderly men), the homeostasis model assessment index (10%), and high-density lipoprotein cholesterol (7%). Conclusion: Our findings demonstrate that 17-glucuronidation of the DHT metabolite androstane-3alpha,17beta-diol is strongly associated with several metabolic risk factors in men. Future longitudinal studies are required to determine the possible impact of the 17G to DHT ratio as a metabolic risk factor in men.

AB - Context: Androgens are associated with metabolic risk factors in men. However, the independent impact of androgens and androgen metabolites on metabolic risk factors in men is unclear. Objective: Our objective was to determine the predictive value of serum levels of androgens and glucuronidated androgen metabolites for metabolic risk factors. Design and Study Subjects: We conducted a population-based study of two Swedish cohorts (1068 young adult and 1001 elderly men). Main Outcome Measures: We measured correlation of serum dihydrotestosterone (DHT), testosterone (T), and glucuronidated androgen metabolites with fat mass, fat distribution, serum lipids, and insulin resistance. Results: Both DHT and T were negatively associated with different measures of fat mass in both cohorts (P < 0.001). Further statistical analysis indicated that DHT, but not T, was independently negatively associated with different measures of fat mass and insulin resistance (P < 0.001). The glucuronidated androgen metabolite androstane-3alpha,17beta-diol-17glucuronide (17G) was independently positively associated with fat mass (P < 0.001). Most importantly, the 17G to DHT ratio was strongly correlated, not only with fat mass but also with central fat distribution, intrahepatic fat, disturbed lipid profile, insulin resistance, and diabetes, explaining a substantial part of the total variance in total body fat (12% in young adult men, 15% in elderly men), the homeostasis model assessment index (10%), and high-density lipoprotein cholesterol (7%). Conclusion: Our findings demonstrate that 17-glucuronidation of the DHT metabolite androstane-3alpha,17beta-diol is strongly associated with several metabolic risk factors in men. Future longitudinal studies are required to determine the possible impact of the 17G to DHT ratio as a metabolic risk factor in men.

U2 - 10.1210/jc.2007-0252

DO - 10.1210/jc.2007-0252

M3 - Article

C2 - 17711928

VL - 92

SP - 4130

EP - 4137

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

SN - 1945-7197

IS - 11

ER -