Animal deoxyribonucleoside kinases: forward and retrograde evolution of their substrate specificity

Research output: Contribution to journalArticle

Abstract

Abstract
Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.

Details

Authors
  • Jure Piskur
  • Michael Sandrini
  • W. Knecht
  • Birgitte Munch-Petersen
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biological Sciences

Keywords

  • nucleic acid precursors, evolution, enzyme, kinases
Original languageEnglish
Pages (from-to)41339
JournalFEBS Letters
Volume560
Issue number1-3
Publication statusPublished - 2004
Publication categoryResearch
Peer-reviewedYes