Animal models of immune thrombocytopenia (ITP)

Research output: Contribution to journalArticle

Abstract

With regards to research animal models related to immune thrombocytopenia (ITP), there is an extensive literature of over 300 publications published since 1959. It appears that many of these models either confirm what has been found in human ITP or, in some instances, are the first to describe a phenomenon related to ITP that is still of relevance today in human medicine. These models will undoubtedly play a significant role in the future research of human ITP particularly related to understanding of the pathogenesis of the disorder and the development of novel therapeutics. This review will highlight some of the major animal models utilized for ITP research and will present a somewhat historical aspect of the subject.

Details

Authors
External organisations
  • University of Toronto
Research areas and keywords

Keywords

  • Animals, Animals, Laboratory, Blood Platelets, Chronic Disease, Disease Models, Animal, Drug-Related Side Effects and Adverse Reactions, Humans, Infection, Purpura, Thrombocytopenic, Idiopathic, Journal Article, Review
Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalAnnals of Hematology
Volume89
Issue numberSuppl 1
Publication statusPublished - 2010 Jul
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes