Animal snoRNAs and scaRNAs with exceptional structures

Research output: Contribution to journalArticle


The overwhelming majority of small nucleolar RNAs (snoRNAs) fall into two clearly defined classes characterized by distinctive secondary structures and sequence motifs. A small group of diverse ncRNAs, however, shares the hallmarks of one or both classes of snoRNAs but differs substantially from the norm in some respects. Here, we compile the available information on these exceptional cases, conduct a thorough homology search throughout the available metazoan genomes, provide improved and expanded alignments, and investigate the evolutionary histories of these ncRNA families as well as their mutual relationships.


  • Manja Marz
  • Andreas R. Gruber
  • Christian Hoener Zu Siederdissen
  • Fabian Amman
  • Stefan Badelt
  • Sebastian Bartschat
  • Stephan H. Bernhart
  • Wolfgang Beyer
  • Stephanie Kehr
  • Ronny Lorenz
  • Andrea Tanzer
  • Dilmurat Yusuf
  • Hakim Tafer
  • Ivo L. Hofacker
  • Peter F. Stadler
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology


  • box C/D, boxH/ACA, scaRNA, evolution, secondary structure
Original languageEnglish
Pages (from-to)938-946
JournalRNA Biology
Issue number6
Publication statusPublished - 2011
Publication categoryResearch