Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation

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Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation. / Alhede, Christina; Lauridsen, Trine K.; Johannessen, Arne; Dixen, Ulrik; Jensen, Jan S.; Raatikainen, Pekka; Hindricks, Gerhard; Walfridsson, Haakan; Kongstad, Ole; Pehrson, Steen; Englund, Anders; Hartikainen, Juha; Hansen, Peter S.; Nielsen, Jens C.; Jons, Christian.

In: International Journal of Cardiology, Vol. 244, 01.10.2017, p. 186-191.

Research output: Contribution to journalArticle

Harvard

Alhede, C, Lauridsen, TK, Johannessen, A, Dixen, U, Jensen, JS, Raatikainen, P, Hindricks, G, Walfridsson, H, Kongstad, O, Pehrson, S, Englund, A, Hartikainen, J, Hansen, PS, Nielsen, JC & Jons, C 2017, 'Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation', International Journal of Cardiology, vol. 244, pp. 186-191. https://doi.org/10.1016/j.ijcard.2017.05.028

APA

Alhede, C., Lauridsen, T. K., Johannessen, A., Dixen, U., Jensen, J. S., Raatikainen, P., Hindricks, G., Walfridsson, H., Kongstad, O., Pehrson, S., Englund, A., Hartikainen, J., Hansen, P. S., Nielsen, J. C., & Jons, C. (2017). Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation. International Journal of Cardiology, 244, 186-191. https://doi.org/10.1016/j.ijcard.2017.05.028

CBE

Alhede C, Lauridsen TK, Johannessen A, Dixen U, Jensen JS, Raatikainen P, Hindricks G, Walfridsson H, Kongstad O, Pehrson S, Englund A, Hartikainen J, Hansen PS, Nielsen JC, Jons C. 2017. Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation. International Journal of Cardiology. 244:186-191. https://doi.org/10.1016/j.ijcard.2017.05.028

MLA

Vancouver

Author

Alhede, Christina ; Lauridsen, Trine K. ; Johannessen, Arne ; Dixen, Ulrik ; Jensen, Jan S. ; Raatikainen, Pekka ; Hindricks, Gerhard ; Walfridsson, Haakan ; Kongstad, Ole ; Pehrson, Steen ; Englund, Anders ; Hartikainen, Juha ; Hansen, Peter S. ; Nielsen, Jens C. ; Jons, Christian. / Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation. In: International Journal of Cardiology. 2017 ; Vol. 244. pp. 186-191.

RIS

TY - JOUR

T1 - Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation

AU - Alhede, Christina

AU - Lauridsen, Trine K.

AU - Johannessen, Arne

AU - Dixen, Ulrik

AU - Jensen, Jan S.

AU - Raatikainen, Pekka

AU - Hindricks, Gerhard

AU - Walfridsson, Haakan

AU - Kongstad, Ole

AU - Pehrson, Steen

AU - Englund, Anders

AU - Hartikainen, Juha

AU - Hansen, Peter S.

AU - Nielsen, Jens C.

AU - Jons, Christian

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background Supraventricular ectopic complexes (SVEC) originating in the pulmonary veins are known triggers of atrial fibrillation (AF) which led to the development of pulmonary vein isolation for AF. However, the long-term prevalence of SVEC after catheter ablation (CA) as compared to antiarrhythmic medication (AAD) is unknown. Our aims were to compare the prevalence of SVEC after AAD and CA and to estimate the association between baseline SVEC burden and AF burden during 24 months of follow-up. Methods Patients with paroxysmal AF (N = 260) enrolled in the MANTRA PAF trial were treated with AAD (N = 132) or CA (N = 128). At baseline and 3, 6, 12, 18 and 24 months follow-up patients underwent 7-day Holter monitoring to assess SVEC and AF burden. We compared SVEC burden between treatments with Wilcoxon sum rank test. Results Patients treated with AAD had significantly lower daily SVEC burden during follow-up as compared to CA (AAD: 19 [6–58] versus CA: 39 [14–125], p = 0.003). SVEC burden increased post-procedurally followed by a decrease after CA whereas after AAD SVEC burden decreased and stabilized after 3 months of follow-up. Patients with low SVEC burden had low AF burden after both treatments albeit this was more pronounced after CA at 24 months of follow-up. Conclusion AAD was superior to CA in suppressing SVEC burden after treatment of paroxysmal AF. After CA SVEC burden increased immediately post-procedural followed by a decrease whereas after AAD an early decrease was observed. Lower SVEC burden was highly associated with lower AF burden during follow-up especially after CA.

AB - Background Supraventricular ectopic complexes (SVEC) originating in the pulmonary veins are known triggers of atrial fibrillation (AF) which led to the development of pulmonary vein isolation for AF. However, the long-term prevalence of SVEC after catheter ablation (CA) as compared to antiarrhythmic medication (AAD) is unknown. Our aims were to compare the prevalence of SVEC after AAD and CA and to estimate the association between baseline SVEC burden and AF burden during 24 months of follow-up. Methods Patients with paroxysmal AF (N = 260) enrolled in the MANTRA PAF trial were treated with AAD (N = 132) or CA (N = 128). At baseline and 3, 6, 12, 18 and 24 months follow-up patients underwent 7-day Holter monitoring to assess SVEC and AF burden. We compared SVEC burden between treatments with Wilcoxon sum rank test. Results Patients treated with AAD had significantly lower daily SVEC burden during follow-up as compared to CA (AAD: 19 [6–58] versus CA: 39 [14–125], p = 0.003). SVEC burden increased post-procedurally followed by a decrease after CA whereas after AAD SVEC burden decreased and stabilized after 3 months of follow-up. Patients with low SVEC burden had low AF burden after both treatments albeit this was more pronounced after CA at 24 months of follow-up. Conclusion AAD was superior to CA in suppressing SVEC burden after treatment of paroxysmal AF. After CA SVEC burden increased immediately post-procedural followed by a decrease whereas after AAD an early decrease was observed. Lower SVEC burden was highly associated with lower AF burden during follow-up especially after CA.

KW - Ablation

KW - Arrhythmia

KW - Premature ectopic beats

KW - Recurrence

KW - Treatment

U2 - 10.1016/j.ijcard.2017.05.028

DO - 10.1016/j.ijcard.2017.05.028

M3 - Article

C2 - 28506548

AN - SCOPUS:85018869747

VL - 244

SP - 186

EP - 191

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -