Antibodies to merkel cell polyomavirus correlate to presence of viral DNA in the skin.

Research output: Contribution to journalArticle

Abstract

To validate whether Merkel cell polyomavirus (MCV) serology correlates with MCV infection, we compared real-time polymerase chain reaction results for MCV DNA on fresh-frozen biopsy specimens from various skin lesions and healthy skin from 434 patients to MCV serology results using viruslike particles (VLPs) and MCV neutralization assays. Sixty-five percent of participants were MCV seropositive and 18% were MCV DNA positive. The presence of antibodies was correlated with the presence of virus DNA (odds ratio, 27.85 [95% confidence interval, 6.6-166.5]), with 97% of patients who tested positive for MCV DNA being MCV seropositive. VLP antibody levels correlated to neutralization titers (r = .72), and high antibody levels correlated to high MCV load (P < .01).

Details

Authors
  • Helena Faust
  • Diana V Pastrana
  • Christopher B Buck
  • Joakim Dillner
  • Johanna Ekström
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
Original languageEnglish
Pages (from-to)1096-1100
JournalJournal of Infectious Diseases
Volume203
Issue number8
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes

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Related research output

Faust, H., 2012, Laboratory Medicine, Medical Microbiology Malmö. 154 p.

Research output: ThesisDoctoral Thesis (compilation)

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