Antibody kinetics and clinical course of COVID-19 a prospective observational study

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title = "Antibody kinetics and clinical course of COVID-19 a prospective observational study",
abstract = "Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. Results Forty patients with COVID-19, hospitalized at Sk{\aa}ne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV- 2 spike protein compared with patients with mild disease. Conclusion IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels. ",
author = "Anna Bl{\"a}ckberg and Nils Fernstr{\"o}m and Emma Sarbrant and Magnus Rasmussen and Torgny Sunnerhagen",
year = "2021",
doi = "10.1371/journal.pone.0248918",
language = "English",
volume = "16",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3 March",