Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.

Research output: Contribution to journalPublished meeting abstract

Abstract

BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.

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Subject classification (UKÄ) – MANDATORY

  • Pediatrics
  • Microbiology in the medical area
Original languageEnglish
Article number172
Pages (from-to)1830-1830
JournalPediatric Nephrology
Volume25
Issue number9
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes
Event15th Congress of the International Pediatric Nephrology Association - New York, NY, United States
Duration: 2010 Aug 292010 Sep 2

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