Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

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Abstract

Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology

Keywords

  • IgA nephropathy, children, group A streptococci, M protein
Original languageEnglish
Pages (from-to)3434-3436
JournalNephrology Dialysis Transplantation
Volume25
Issue number10
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes