Antileishmanial metabolites from Lantana balansae

Research output: Contribution to journalArticle

Abstract

Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.

Details

Authors
  • Eliana M. Maldonado
  • Efrain Salamanca
  • Alberto Giménez
  • Olov Sterner
Organisations
External organisations
  • Universidad Mayor de San Simon
  • Higher University of San Andrés
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmaceutical Sciences

Keywords

  • 12-oxo-phytodienoic acid, Flavonoids, L. braziliensis, Lantana balansae, Leishmania amazonensis
Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalBrazilian Journal of Pharmacognosy
Volume26
Issue number2
Publication statusPublished - 2016 Jan 1
Publication categoryResearch
Peer-reviewedYes