Antileishmanial metabolites from Trixis antimenorrhoea

Research output: Contribution to journalArticle

Abstract

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Details

Authors
  • Eliana Maldonado
  • Efrain Salamanca
  • Alberto Gimenez
  • Gloria Saavedra
  • Olov Sterner
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Chemical Sciences

Keywords

  • Trixis antimenorrhoea, Nortrixane, Trixanolide, Antileishmanial, activity, Structural elucidation
Original languageEnglish
Pages (from-to)281-286
JournalPhytochemistry Letters
Volume10
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes