Antiproliferative effects of curcumin analog L49H37 in pancreatic stellate cells: a comparative study.

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Abstract

Pancreatic cancer is a devastating disease with poor prognosis. It is characterized by a pronounced stromal reaction, which resists chemotherapeutics and effective tumor treatment. Pancreatic stellate cells (PSCs) are mainly responsible for this stromal reaction. Moreover, the cancer and stromal interaction seems to promote tumor proliferation. In this study, L49H37, a newly synthesized curcumin analog, was used as intervention to target the stromal compartment of pancreatic cancer.

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Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)391-398
JournalAnnals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology
Volume28
Issue number3
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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