Antisense RNAs everywhere?

Research output: Contribution to journalReview article

Abstract

In recent years, systematic searches of both prokaryote and eukaryote genomes have identified a staggering number of small RNAs, the biological functions of which remain unknown. Small RNA-based regulators are well known from bacterial plasmids. They act on target RNAs by sequence complementarity; that is, they are antisense RNAs. Recent findings suggest that many of the novel orphan RNAs encoded by bacterial and eukaryotic chromosomes might also belong to a ubiquitous, heterogeneous class of antisense regulators of gene expression.

Details

Authors
External organisations
  • Uppsala University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biological Sciences

Keywords

  • bacteria, plasmid, riboregulator, antisense RNA, non-coding RNA, gene silencing
Original languageEnglish
Pages (from-to)223-226
JournalTrends in Genetics
Volume18
Issue number5
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes