Anti-trypanosomal alkaloids from Xymalos monospora

Research output: Contribution to journalArticle

Abstract

From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.

Details

Authors
  • Dieudonne Ngarnga
  • Pierre Tane
  • Donna Rattendi
  • Cyrus Bacchi
  • Christopher C. Okunji
  • Maurice M. Iwu
  • Brian M. Schuster
  • Olov Sterner
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry

Keywords

  • trypanosomiasis, antitrypanosomal, alkaloids, Xymalos monospora, monimiaceae, sleeping sickness
Original languageEnglish
Pages (from-to)619-622
JournalNatural Product Communications
Volume1
Issue number8
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)