Anti-trypanosomal alkaloids from Xymalos monospora

Research output: Contribution to journalArticle


title = "Anti-trypanosomal alkaloids from Xymalos monospora",
abstract = "From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.",
keywords = "trypanosomiasis, antitrypanosomal, alkaloids, Xymalos monospora, monimiaceae, sleeping sickness",
author = "Dieudonne Ngarnga and Pierre Tane and Donna Rattendi and Cyrus Bacchi and Okunji, {Christopher C.} and Iwu, {Maurice M.} and Schuster, {Brian M.} and Olov Sterner",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",
year = "2006",
language = "English",
volume = "1",
pages = "619--622",
journal = "Natural Product Communications",
issn = "1934-578X",
publisher = "Natural Products Inc",
number = "8",