Anti-trypanosomal alkaloids from Xymalos monospora

Research output: Contribution to journalArticle

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Anti-trypanosomal alkaloids from Xymalos monospora. / Ngarnga, Dieudonne; Tane, Pierre; Rattendi, Donna; Bacchi, Cyrus; Okunji, Christopher C.; Iwu, Maurice M.; Schuster, Brian M.; Sterner, Olov.

In: Natural Product Communications, Vol. 1, No. 8, 2006, p. 619-622.

Research output: Contribution to journalArticle

Harvard

Ngarnga, D, Tane, P, Rattendi, D, Bacchi, C, Okunji, CC, Iwu, MM, Schuster, BM & Sterner, O 2006, 'Anti-trypanosomal alkaloids from Xymalos monospora', Natural Product Communications, vol. 1, no. 8, pp. 619-622.

APA

Ngarnga, D., Tane, P., Rattendi, D., Bacchi, C., Okunji, C. C., Iwu, M. M., ... Sterner, O. (2006). Anti-trypanosomal alkaloids from Xymalos monospora. Natural Product Communications, 1(8), 619-622.

CBE

Ngarnga D, Tane P, Rattendi D, Bacchi C, Okunji CC, Iwu MM, Schuster BM, Sterner O. 2006. Anti-trypanosomal alkaloids from Xymalos monospora. Natural Product Communications. 1(8):619-622.

MLA

Vancouver

Ngarnga D, Tane P, Rattendi D, Bacchi C, Okunji CC, Iwu MM et al. Anti-trypanosomal alkaloids from Xymalos monospora. Natural Product Communications. 2006;1(8):619-622.

Author

Ngarnga, Dieudonne ; Tane, Pierre ; Rattendi, Donna ; Bacchi, Cyrus ; Okunji, Christopher C. ; Iwu, Maurice M. ; Schuster, Brian M. ; Sterner, Olov. / Anti-trypanosomal alkaloids from Xymalos monospora. In: Natural Product Communications. 2006 ; Vol. 1, No. 8. pp. 619-622.

RIS

TY - JOUR

T1 - Anti-trypanosomal alkaloids from Xymalos monospora

AU - Ngarnga, Dieudonne

AU - Tane, Pierre

AU - Rattendi, Donna

AU - Bacchi, Cyrus

AU - Okunji, Christopher C.

AU - Iwu, Maurice M.

AU - Schuster, Brian M.

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2006

Y1 - 2006

N2 - From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.

AB - From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.

KW - trypanosomiasis

KW - antitrypanosomal

KW - alkaloids

KW - Xymalos monospora

KW - monimiaceae

KW - sleeping sickness

M3 - Article

VL - 1

SP - 619

EP - 622

JO - Natural Product Communications

JF - Natural Product Communications

SN - 1934-578X

IS - 8

ER -