Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer Disease.

Research output: Contribution to journalArticle

Abstract

Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.

Details

Authors
  • Ronald Lautner
  • Sebastian Palmqvist
  • Niklas Mattsson
  • Ulf Andreasson
  • Anders Wallin
  • Erik Pålsson
  • Joel Jakobsson
  • Sanna-Kaisa Herukka
  • Rikard Owenius
  • Bob Olsson
  • Harald Hampel
  • Dan Rujescu
  • Michael Ewers
  • Mikael Landén
  • Lennart Minthon
  • Kaj Blennow
  • Henrik Zetterberg
  • Oskar Hansson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Psychiatry
Original languageEnglish
Pages (from-to)1183-1191
JournalJAMA Psychiatry
Volume71
Issue number10
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

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