Apolipoprotein E genotypes and longevity across dementia disorders

Research output: Contribution to journalArticle


Introduction: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. Results: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P =.006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P =.028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. Discussion: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.


  • Tobias Skillbäck
  • Ronald Lautner
  • Niklas Mattsson
  • Jonathan M. Schott
  • Katarina Nägga
  • Lena Kilander
  • Anders Wimo
  • Bengt Winblad
  • Maria Eriksdotter
  • Kaj Blennow
  • Henrik Zetterberg
External organisations
  • Sahlgrenska Academy
  • Sahlgrenska University Hospital
  • Skåne University Hospital
  • University College London
  • Uppsala University
  • Karolinska Institutet
  • Karolinska University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology


  • Alzheimer's disease, Apolipoprotein E, Creutzfeldt-Jakob disease, Dementia with Lewy bodies, Frontotemporal dementia, Parkinson's disease dementia, Vascular dementia
Original languageEnglish
Pages (from-to)895-901
JournalAlzheimer's and Dementia
Issue number7
Early online date2018 Jan 1
Publication statusPublished - 2018 Jul
Publication categoryResearch