Apolipoprotein E genotypes and longevity across dementia disorders

Research output: Contribution to journalArticle

Abstract

Introduction: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. Results: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P =.006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P =.028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. Discussion: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.

Details

Authors
  • Tobias Skillbäck
  • Ronald Lautner
  • Niklas Mattsson
  • Jonathan M. Schott
  • Katarina Nägga
  • Lena Kilander
  • Anders Wimo
  • Bengt Winblad
  • Maria Eriksdotter
  • Kaj Blennow
  • Henrik Zetterberg
Organisations
External organisations
  • Sahlgrenska Academy
  • Sahlgrenska University Hospital
  • Skåne University Hospital
  • University College London
  • Uppsala University
  • Karolinska Institutet
  • Karolinska University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, Apolipoprotein E, Creutzfeldt-Jakob disease, Dementia with Lewy bodies, Frontotemporal dementia, Parkinson's disease dementia, Vascular dementia
Original languageEnglish
Pages (from-to)895-901
JournalAlzheimer's and Dementia
Volume14
Issue number7
Early online date2018 Jan 1
Publication statusPublished - 2018 Jul
Publication categoryResearch
Peer-reviewedYes