Apolipoprotein M promotes proliferation and invasion in non-small cell lung cancers via upregulating S1PR1 and activating the ERK1/2 and PI3K/AKT signaling pathways

Research output: Contribution to journalArticle

Abstract

Apolipoprotein M (ApoM) is a sphingosine 1-phosphate (S1P) carrier involved in the regulation of S1P. Signaling pathways involving sphingosine kinases (SphKs) and S1P-S1P receptors (S1PRs) play important roles in the oncogenesis of multiple cancers including non-small cell lung cancer (NSCLC). In the present study we have clarified the potential roles of ApoM on the oncogenesis process of NSCLC cells. We detected the ApoM expression in NSCLC tissues and further analyzed its clinical significance. Moreover, we determined effects of ApoM overexpression on tumor cellular behaviours of NSCLC in vitro and in vivo. Our results demonstrated that ApoM protein mass were clearly higher in the NSCLC tissues than in non-NSCLS tissues. Overexpression of ApoM could promote NSCLC cell proliferation and invasion in vitro and tumor growth in vivo, which might be via upregulating S1PR1 and activating the ERK1/2 and PI3K/AKT signaling pathways. It is concluded that up-regulation of ApoM in NSCLC might be associated with the tumor induced inflammation and tumor microenvironment as well as promoting oncogenesis of NSCLC. Further study needs to elucidate the underlying mechanisms.

Details

Authors
  • Yifei Zhu
  • Guanghua Luo
  • Bo Jiang
  • Miaomei Yu
  • Yuehua Feng
  • Min Wang
  • Ning Xu
  • Xiaoying Zhang
Organisations
External organisations
  • Third Affiliated Hospital of Soochow University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
  • Cancer and Oncology

Keywords

  • Apolipoprotein M, ERK1/2 signal pathway, Non-small cell lung cancer, PI3K/AKT signal pathway, Sphingosine 1-phosphate receptors
Original languageEnglish
Pages (from-to)520-526
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume501
Issue number2
Publication statusPublished - 2018 Jun 22
Publication categoryResearch
Peer-reviewedYes