Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus

Research output: Contribution to journalArticle

Abstract

Islet cell antibodies (ICA) and glutamic acid decarboxylase antibodies (GAD65Ab) are often present at diagnosis of insulin dependent diabetes mellitus (type I diabetes) and are supposed to decline in level and frequency during the first years of disease. We have analysed ICA and GAD65Ab at onset and after one gear in 395 population based randomly selected 15-34 year old patients newly diagnosed with diabetes mellitus, to study how these autoantibodies persist, disappear and appear and their relation to C-peptide levels. Of the 395 samples 212 (54%) were positive for ICA, 250 (63%) were positive for GAD65Ab and 170 (43%) were positive for both. At follow up after one year, 27/183 (15%) of the ICA negative patients and 25/145 (17%) of the GAD65Ab negative patients had converted to positivity. Among the 103 patients negative for both ICA and GAD65Ab, 16 turned positive for one or both antibodies after one year. Patients converting to positivity for one or the other antibody after one year, had lower C-peptide levels after one year than patients who initially were and remained negative, supporting the hypothesis that these patients have a genuine type I diabetes. In conclusion, newly diagnosed patients may be negative for autoantibodies at diagnosis but develop these antibodies later on during the disease.

Details

Authors
  • Mona Landin-Olsson
  • Hans J. Arnqvist
  • Göran Blohmé
  • Bengt Littorin
  • Folke Lithner
  • Lennarth Nyström
  • Bengt Scherstén
  • Göran Sundkvist
  • Lars Wibell
  • Jan Östman
  • Åke Lernmark
Organisations
External organisations
  • Sahlgrenska University Hospital
  • Norrland University Hospital
  • Uppsala University Hospital
  • University of Washington, Seattle
Research areas and keywords

Keywords

  • Autoimmunity, C-peptide, GAD65 antibodies, Islet cell antibodies
Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalAutoimmunity
Volume29
Issue number1
Publication statusPublished - 1999 Jan 1
Publication categoryResearch
Peer-reviewedYes