Applications of nanodiamonds in the detection and therapy of infectious diseases

Research output: Contribution to journalReview article


We are constantly exposed to infectious diseases, and they cause millions of deaths per year. TheWorld Health Organization (WHO) estimates that antibiotic resistance could cause 10 million deaths per year by 2050. Multidrug-resistant bacteria are the cause of infection in at least one in three people suffering from septicemia. While antibiotics are powerful agents against infectious diseases, the alarming increase in antibiotic resistance is of great concern. Alternatives are desperately needed, and nanotechnology provides a great opportunity to develop novel approaches for the treatment of infectious diseases. One of the most important factors in the prognosis of an infection caused by an antibiotic resistant bacteria is an early and rigorous diagnosis, jointly with the use of novel therapeutic systems that can specifically target the pathogen and limit the selection of resistant strains. Nanodiamonds can be used as antimicrobial agents due to some of their properties including size, shape, and biocompatibility, which make them highly suitable for the development of efficient and tailored nanotherapies, including vaccines or drug delivery systems. In this review, we discuss the beneficial findings made in the nanodiamonds field, focusing on diagnosis and treatment of infectious diseases. We also highlight the innovative platform that nanodiamonds confer for vaccine improvement, drug delivery, and shuttle systems, as well as their role in the generation of faster and more sensitive clinical diagnosis.


  • Eva Torres Sangiao
  • Alina Maria Holban
  • Mónica Cartelle Gestal
External organisations
  • University Politehnica of Bucharest
  • University of Georgia
  • Complejo Hospitalario Universitario de Santiago
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine


  • Antibiotic resistance, Diagnosis, Microbiology, Nanodiamonds, Vaccines
Original languageEnglish
Article number1639
Issue number10
Publication statusPublished - 2019
Publication categoryResearch