Arynes in the Monoarylation of Unprotected Carbohydrate Amines

Research output: Contribution to journalArticle

Abstract

A CsF-mediated method has been developed for the N-arylation of amino sugars that affords good to excellent yields of arylated products under mild conditions involving the in situ generation of arynes. The reaction conditions tolerate a variety of common carbohydrate protecting groups and also performs exceptionally well on unprotected amino sugar derivatives. The reactions are scalable in moderate to good yields with broad scope.

Details

Authors
Organisations
External organisations
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)616-619
Number of pages4
JournalOrganic Letters
Volume20
Issue number3
Publication statusPublished - 2018 Feb 2
Publication categoryResearch
Peer-reviewedYes