Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study

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Assessment of moderate coffee consumption and risk of epithelial ovarian cancer : a Mendelian randomization study. / Ong, Jue-Sheng; Hwang, Liang-Dar; Cuellar-Partida, Gabriel; Martin, Nicholas G; Chenevix-Trench, Georgia; Quinn, Michael C J; Cornelis, Marilyn C; Gharahkhani, Puya; Webb, Penelope M; MacGregor, Stuart; Olsson, Håkan (Contributor); Ovarian Cancer Association Consortium.

In: International Journal of Epidemiology, Vol. 47, No. 2, 01.04.2018, p. 450-459.

Research output: Contribution to journalArticle

Harvard

Ong, J-S, Hwang, L-D, Cuellar-Partida, G, Martin, NG, Chenevix-Trench, G, Quinn, MCJ, Cornelis, MC, Gharahkhani, P, Webb, PM, MacGregor, S, Olsson, H & Ovarian Cancer Association Consortium 2018, 'Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study', International Journal of Epidemiology, vol. 47, no. 2, pp. 450-459. https://doi.org/10.1093/ije/dyx236

APA

Ong, J-S., Hwang, L-D., Cuellar-Partida, G., Martin, N. G., Chenevix-Trench, G., Quinn, M. C. J., ... Ovarian Cancer Association Consortium (2018). Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. International Journal of Epidemiology, 47(2), 450-459. https://doi.org/10.1093/ije/dyx236

CBE

Ong J-S, Hwang L-D, Cuellar-Partida G, Martin NG, Chenevix-Trench G, Quinn MCJ, Cornelis MC, Gharahkhani P, Webb PM, MacGregor S, Olsson H, Ovarian Cancer Association Consortium. 2018. Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. International Journal of Epidemiology. 47(2):450-459. https://doi.org/10.1093/ije/dyx236

MLA

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Author

Ong, Jue-Sheng ; Hwang, Liang-Dar ; Cuellar-Partida, Gabriel ; Martin, Nicholas G ; Chenevix-Trench, Georgia ; Quinn, Michael C J ; Cornelis, Marilyn C ; Gharahkhani, Puya ; Webb, Penelope M ; MacGregor, Stuart ; Olsson, Håkan ; Ovarian Cancer Association Consortium. / Assessment of moderate coffee consumption and risk of epithelial ovarian cancer : a Mendelian randomization study. In: International Journal of Epidemiology. 2018 ; Vol. 47, No. 2. pp. 450-459.

RIS

TY - JOUR

T1 - Assessment of moderate coffee consumption and risk of epithelial ovarian cancer

T2 - International Journal of Epidemiology

AU - Ong, Jue-Sheng

AU - Hwang, Liang-Dar

AU - Cuellar-Partida, Gabriel

AU - Martin, Nicholas G

AU - Chenevix-Trench, Georgia

AU - Quinn, Michael C J

AU - Cornelis, Marilyn C

AU - Gharahkhani, Puya

AU - Webb, Penelope M

AU - MacGregor, Stuart

AU - Ovarian Cancer Association Consortium

A2 - Olsson, Håkan

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

AB - Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

KW - Carcinoma, Ovarian Epithelial/epidemiology

KW - Coffee/adverse effects

KW - Female

KW - Humans

KW - Mendelian Randomization Analysis

KW - Odds Ratio

KW - Ovarian Neoplasms/epidemiology

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

U2 - 10.1093/ije/dyx236

DO - 10.1093/ije/dyx236

M3 - Article

VL - 47

SP - 450

EP - 459

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 1464-3685

IS - 2

ER -