Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort: The ABIDE project

Research output: Contribution to journalArticle

Abstract

Introduction: The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort. Methods: We calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in post–positron emission tomography diagnosis and management change between “AUC-consistent” and “AUC-inconsistent” patients. Results: Almost half (250/507) of patients were AUC-consistent. In both AUC-consistent and AUC-inconsistent patients, post–positron emission tomography diagnosis (28%–21%) and management (32%–17%) change was substantial. The Amyloid Imaging Taskforce's definition of appropriate use occurred in 55/507 (13%) patients, detected by the AUC with a sensitivity of 93%, and a specificity of 56%. Diagnostic changes occurred independently of AUC status (sensitivity: 57%, specificity: 53%). Discussion: The current AUC are not sufficiently able to discriminate between patients who will benefit from amyloid positron emission tomography and those who will not.

Details

Authors
  • Arno de Wilde
  • Rik Ossenkoppele
  • Wiesje Pelkmans
  • Femke Bouwman
  • Colin Groot
  • Ingrid van Maurik
  • Marissa Zwan
  • Maqsood Yaqub
  • Frederik Barkhof
  • Adriaan A. Lammertsma
  • Geert Jan Biessels
  • Philip Scheltens
  • Bart N. van Berckel
  • Wiesje M. van der Flier
Organisations
External organisations
  • University College London
  • University Medical Center Utrecht
  • Vrije Universiteit Amsterdam
  • Amsterdam UMC - Vrije Universiteit Amsterdam
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, Amyloid, Appropriate use criteria, Clinical practice, Dementia, Positron emission tomography
Original languageEnglish
JournalAlzheimer's and Dementia
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes