Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat
Research output: Contribution to journal › Article
Two different factor V cDNA fragments were used as hydridization probes in the chromosomal assignment of the human and rat factor V genes. A 1.6-kb EcoRI fragment was used as a hybridization probe to analyze a panel of human-rodent somatic cell hybrids. Cosegregation of factor V specific DNA restriction fragments with human chromosome 1 was observed. In addition, a panel of rat-mouse somatic cell hybrids was analyzed with another human factor V cDNA probe to localize the gene for rat coagulation factor V. In the rat, the gene for coagulation factor V was found to be located in chromosome 13. This is the first gene in the rat to be localized to chromosome 13.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Somat Cell Mol Genet|
|Publication status||Published - 1988|