Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients

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Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients. / Hemminki, Kari; Sundquist, Jan; Bermejo, Justo L.

In: British Journal of Haematology, Vol. 147, No. 4, 2009, p. 526-530.

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TY - JOUR

T1 - Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients

AU - Hemminki, Kari

AU - Sundquist, Jan

AU - Bermejo, Justo L.

PY - 2009

Y1 - 2009

N2 - Polycythaemia vera (PV) and primary myelofibrosis (MF) show concordant familial clustering but limited population level data are available on the aggregation of other discordant neoplasms in these families. We used the Swedish Family-Cancer Database to assess risks for VP and MF in families of cancer patients. A total of 3530 first PV and 1606 MF patients were identified, with high concordant familial risks. Several discordant familial associations were found for PV (acute myeloid leukaemia, Hodgkin disease, prostate and bladder cancers) or for MF (chronic lymphatic leukaemia, colorectal, kidney and cervical cancers) or for both (nervous system, eye and endocrine tumours).

AB - Polycythaemia vera (PV) and primary myelofibrosis (MF) show concordant familial clustering but limited population level data are available on the aggregation of other discordant neoplasms in these families. We used the Swedish Family-Cancer Database to assess risks for VP and MF in families of cancer patients. A total of 3530 first PV and 1606 MF patients were identified, with high concordant familial risks. Several discordant familial associations were found for PV (acute myeloid leukaemia, Hodgkin disease, prostate and bladder cancers) or for MF (chronic lymphatic leukaemia, colorectal, kidney and cervical cancers) or for both (nervous system, eye and endocrine tumours).

KW - family history

KW - leukaemia

KW - polycythaemia vera

KW - myelofibrosis

KW - discordant cancers

U2 - 10.1111/j.1365-2141.2009.07874.x

DO - 10.1111/j.1365-2141.2009.07874.x

M3 - Article

VL - 147

SP - 526

EP - 530

JO - British Journal of Haematology

T2 - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 4

ER -