Association between Erectile Function and Biomarkers of Subclinical Atherosclerosis: A Study Based on Middle-Aged Healthy Men from the General Population

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Association between Erectile Function and Biomarkers of Subclinical Atherosclerosis : A Study Based on Middle-Aged Healthy Men from the General Population. / Elzanaty, Saad; REZANEZHAD ZANJANI, BABAK; Willenheimer, Ronnie; Borgquist, Rasmus.

In: Current Urology, Vol. 9, No. 3, 01.10.2016, p. 119-123.

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TY - JOUR

T1 - Association between Erectile Function and Biomarkers of Subclinical Atherosclerosis

T2 - A Study Based on Middle-Aged Healthy Men from the General Population

AU - Elzanaty, Saad

AU - REZANEZHAD ZANJANI, BABAK

AU - Willenheimer, Ronnie

AU - Borgquist, Rasmus

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Introduction: Epidemiological studies suggest atherosclerosis as a common risk factor between cardiovascular diseases and erectile dysfunction (ED). We aimed to determine the association between erectile function and the biomarkers of subclinical atherosclerosis in 119 middle-aged healthy men from the general population. Methods: Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5). Serum levels of biomarkers of atherosclerosis: Apolipoprotein A, Apolipoprotein B, fibrinogen, and C-reactive protein (CRP) were measured. In addition, demographic data was collected. Results: The mean (SD) of age was 55 years (± 4.0). The prevalence of ED was 50%. There was a negative significant correlation between IIEF-5 and CRP levels (r = -0.20, p = 0.02), and BMI (r = -0.20, p = 0.03), respectively. No significant correlations between IIEF-5 and serum levels of Apolipoprotein A, Apolipoprotein B, and fibrinogen were found (p > 0.05). A positive significant correlation was found between BMI and fibrinogen (r = 0.20, p = 0.01), CRP (r = 0.30, p = 0.001). In a multivariate logistic regression model with IIEF-5 as the dependent variable, CRP was the only biomarker that predicted ED (odds ratio = 1.350; 95 % CI: 1.044-1.754). Conclusions: These results indicate that CRP is a biomarker of subclinical atherosclerosis associated with ED. This association seems to be linked to greater BMI among such men.

AB - Introduction: Epidemiological studies suggest atherosclerosis as a common risk factor between cardiovascular diseases and erectile dysfunction (ED). We aimed to determine the association between erectile function and the biomarkers of subclinical atherosclerosis in 119 middle-aged healthy men from the general population. Methods: Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5). Serum levels of biomarkers of atherosclerosis: Apolipoprotein A, Apolipoprotein B, fibrinogen, and C-reactive protein (CRP) were measured. In addition, demographic data was collected. Results: The mean (SD) of age was 55 years (± 4.0). The prevalence of ED was 50%. There was a negative significant correlation between IIEF-5 and CRP levels (r = -0.20, p = 0.02), and BMI (r = -0.20, p = 0.03), respectively. No significant correlations between IIEF-5 and serum levels of Apolipoprotein A, Apolipoprotein B, and fibrinogen were found (p > 0.05). A positive significant correlation was found between BMI and fibrinogen (r = 0.20, p = 0.01), CRP (r = 0.30, p = 0.001). In a multivariate logistic regression model with IIEF-5 as the dependent variable, CRP was the only biomarker that predicted ED (odds ratio = 1.350; 95 % CI: 1.044-1.754). Conclusions: These results indicate that CRP is a biomarker of subclinical atherosclerosis associated with ED. This association seems to be linked to greater BMI among such men.

KW - Atherosclerosis

KW - CRP

KW - Erectile dysfunction

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84992380030&partnerID=8YFLogxK

U2 - 10.1159/000442865

DO - 10.1159/000442865

M3 - Article

VL - 9

SP - 119

EP - 123

JO - Current Urology

JF - Current Urology

SN - 1661-7649

IS - 3

ER -