Association of adenomatous polyposis coli (APC) gene polymorphisms with autism spectrum disorder (ASD)

Research output: Contribution to journalArticle


We serendipitously identified a single nucleotide polymorphism (SNP), 8636C > A (rs1804197) in the T-untranslated region of the adenomatous polyposis coli (APC) gene to be associated with autism spectrum disorder (ASD). In order to gain further evidence for the association between the APC locus and ASD, we genotyped four additional adjacent common SNPs (rs2229992, rs42427, rs459552, and rs465899) in the coding regions within the APC gene in a set of Swedish ASDs and controls. One common haplotype TGAG was found to be associated with ASD after haplotype analysis using both Haploview v3.1.1 (P = 0.006) and COCAPHASE v2.403 (P = 0.030). This result is the first to suggest that the genomic locus at APC is associated with ASD, and that the APC gene itself is a good predisposing candidate to be evaluated in future studies due to its important role in neuronal development and function.


  • Xiao-Lei Zhou
  • MaiBritt Giacobini
  • Britt-Marie Anderlid
  • Henrik Anckarsäter
  • Davood Omrani
  • Christopher Gillberg
  • Magnus Nordenskjold
  • Annika Lindblom
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Psychiatry


  • autism spectrum disorder (ASD), haplotype, APC, SNP, association
Original languageEnglish
Pages (from-to)351-354
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Issue number3
Publication statusPublished - 2007
Publication categoryResearch