Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina

Research output: Contribution to journalArticle

Abstract

Previous studies reported conflicting results regarding association of insulin receptor substrate 1 (IRS1) gene variation with type 2 diabetes (T2D) and insulin resistance (IR) in different ethnic groups. We examined the association of rs7578326, rs2943641, and rs4675095 in the IRS1 gene with T2D and related traits in a population from Bosnia and Herzegovina, which is one of the European countries with the highest T2D prevalence of 12.5%. Our study included 390 T2D patients and 252 control subjects. Biochemical parameters, including fasting glucose (FG), fasting insulin (FI), homeostasis model assessment insulin resistance index (HOMA-IR), and HbA 1c were measured in all participants. Genotyping analysis was performed by Mass Array Sequenom iPlex platform. Our results demonstrated that rs7578326 and rs4675095 variants were associated with increased FG levels. The rs7578326 was also associated with higher FI, HOMA-IR (B = 0.08, 95% CI [0.01, 0.15], p add = 0.025; B = 0.079, 95% CI [0.006, 0.150], p add = 0.033, respectively) in T2D, and with HbA 1c (B = 0.034, 95% CI [0.003, 0.065], p dom = 0.035) in non-drug-treated T2D. In contrast, rs2943641 C allele was associated with lower FG levels in control subjects (B = -0.17, 95% CI [-0.03, -0.002], p add = 0.030) and HbA 1c (B = 0.03, 95% CI [0.002, 0.06], p dom = 0.040) in non-drug-treated T2D. We report the association between common variants in IRS1 gene with insulin resistance, glucose, and HbA 1c levels in Bosnia and Herzegovina's population.

Details

Authors
  • Lejla Mahmutovic
  • Tamer Bego
  • Maria Sterner
  • Gabriella Gremsperger
  • Emma Ahlqvist
  • Zelija Velija Asimi
  • Besim Prnjavorac
  • Nour Hamad
  • Adlija Causevic
  • Leif Groop
  • Sabina Semiz
Organisations
External organisations
  • University of Sarajevo
  • General Hospital Tesanj
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • fasting glucose, HbA, HOMA-IR, insulin resistance, IRS1, single nucleotide polymorphism
Original languageEnglish
Article number20180031
JournalDrug Metabolism and Personalized Therapy
Volume34
Issue number1
Early online date2019
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes