Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Research output: Contribution to journalArticle

Abstract

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

Details

Authors
  • Kevin Luk
  • James C Engert
  • Ron Do
  • Gull Rukh
  • Line Dufresne
  • Peter Almgren
  • David S Owens
  • Tamara B Harris
  • Gina M Peloso
  • Kathleen F Kerr
  • Quenna Wong
  • Albert V Smith
  • Matthew J Budoff
  • Jerome I Rotter
  • L Adrienne Cupples
  • Stephen Rich
  • Sekar Kathiresan
  • Vilmundur Gudnason
  • Christopher J O'Donnell
  • Wendy S Post
  • George Thanassoulis
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)1764-1771
JournalJAMA: The Journal of the American Medical Association
Volume312
Issue number17
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes