Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Research output: Contribution to journalArticle

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Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis. / Smith, Gustav; Luk, Kevin; Schulz, Christina-Alexandra; Engert, James C; Do, Ron; Hindy, George; Rukh, Gull; Dufresne, Line; Almgren, Peter; Owens, David S; Harris, Tamara B; Peloso, Gina M; Kerr, Kathleen F; Wong, Quenna; Smith, Albert V; Budoff, Matthew J; Rotter, Jerome I; Cupples, L Adrienne; Rich, Stephen; Kathiresan, Sekar; Orho-Melander, Marju; Gudnason, Vilmundur; O'Donnell, Christopher J; Post, Wendy S; Thanassoulis, George.

In: JAMA: The Journal of the American Medical Association, Vol. 312, No. 17, 2014, p. 1764-1771.

Research output: Contribution to journalArticle

Harvard

Smith, G, Luk, K, Schulz, C-A, Engert, JC, Do, R, Hindy, G, Rukh, G, Dufresne, L, Almgren, P, Owens, DS, Harris, TB, Peloso, GM, Kerr, KF, Wong, Q, Smith, AV, Budoff, MJ, Rotter, JI, Cupples, LA, Rich, S, Kathiresan, S, Orho-Melander, M, Gudnason, V, O'Donnell, CJ, Post, WS & Thanassoulis, G 2014, 'Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.', JAMA: The Journal of the American Medical Association, vol. 312, no. 17, pp. 1764-1771. https://doi.org/10.1001/jama.2014.13959

APA

Smith, G., Luk, K., Schulz, C-A., Engert, J. C., Do, R., Hindy, G., Rukh, G., Dufresne, L., Almgren, P., Owens, D. S., Harris, T. B., Peloso, G. M., Kerr, K. F., Wong, Q., Smith, A. V., Budoff, M. J., Rotter, J. I., Cupples, L. A., Rich, S., ... Thanassoulis, G. (2014). Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis. JAMA: The Journal of the American Medical Association, 312(17), 1764-1771. https://doi.org/10.1001/jama.2014.13959

CBE

Smith G, Luk K, Schulz C-A, Engert JC, Do R, Hindy G, Rukh G, Dufresne L, Almgren P, Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q, Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich S, Kathiresan S, Orho-Melander M, Gudnason V, O'Donnell CJ, Post WS, Thanassoulis G. 2014. Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis. JAMA: The Journal of the American Medical Association. 312(17):1764-1771. https://doi.org/10.1001/jama.2014.13959

MLA

Vancouver

Author

Smith, Gustav ; Luk, Kevin ; Schulz, Christina-Alexandra ; Engert, James C ; Do, Ron ; Hindy, George ; Rukh, Gull ; Dufresne, Line ; Almgren, Peter ; Owens, David S ; Harris, Tamara B ; Peloso, Gina M ; Kerr, Kathleen F ; Wong, Quenna ; Smith, Albert V ; Budoff, Matthew J ; Rotter, Jerome I ; Cupples, L Adrienne ; Rich, Stephen ; Kathiresan, Sekar ; Orho-Melander, Marju ; Gudnason, Vilmundur ; O'Donnell, Christopher J ; Post, Wendy S ; Thanassoulis, George. / Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis. In: JAMA: The Journal of the American Medical Association. 2014 ; Vol. 312, No. 17. pp. 1764-1771.

RIS

TY - JOUR

T1 - Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

AU - Smith, Gustav

AU - Luk, Kevin

AU - Schulz, Christina-Alexandra

AU - Engert, James C

AU - Do, Ron

AU - Hindy, George

AU - Rukh, Gull

AU - Dufresne, Line

AU - Almgren, Peter

AU - Owens, David S

AU - Harris, Tamara B

AU - Peloso, Gina M

AU - Kerr, Kathleen F

AU - Wong, Quenna

AU - Smith, Albert V

AU - Budoff, Matthew J

AU - Rotter, Jerome I

AU - Cupples, L Adrienne

AU - Rich, Stephen

AU - Kathiresan, Sekar

AU - Orho-Melander, Marju

AU - Gudnason, Vilmundur

AU - O'Donnell, Christopher J

AU - Post, Wendy S

AU - Thanassoulis, George

PY - 2014

Y1 - 2014

N2 - Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

AB - Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

U2 - 10.1001/jama.2014.13959

DO - 10.1001/jama.2014.13959

M3 - Article

C2 - 25344734

VL - 312

SP - 1764

EP - 1771

JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

SN - 0098-7484

IS - 17

ER -