Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

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Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. / Lotvall, Jan; Akdis, Cezmi A.; Bacharier, Leonard B.; Bjermer, Leif; Casale, Thomas B.; Custovic, Adnan; Lemanske, Robert F.; Wardlaw, Andrew J.; Wenzel, Sally E.; Greenberger, Paul A.

In: Journal of Allergy and Clinical Immunology, Vol. 127, No. 2, 2011, p. 355-360.

Research output: Contribution to journalArticle

Harvard

Lotvall, J, Akdis, CA, Bacharier, LB, Bjermer, L, Casale, TB, Custovic, A, Lemanske, RF, Wardlaw, AJ, Wenzel, SE & Greenberger, PA 2011, 'Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome', Journal of Allergy and Clinical Immunology, vol. 127, no. 2, pp. 355-360. https://doi.org/10.1016/j.jaci.2010.11.037

APA

CBE

Lotvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, Lemanske RF, Wardlaw AJ, Wenzel SE, Greenberger PA. 2011. Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. Journal of Allergy and Clinical Immunology. 127(2):355-360. https://doi.org/10.1016/j.jaci.2010.11.037

MLA

Vancouver

Author

Lotvall, Jan ; Akdis, Cezmi A. ; Bacharier, Leonard B. ; Bjermer, Leif ; Casale, Thomas B. ; Custovic, Adnan ; Lemanske, Robert F. ; Wardlaw, Andrew J. ; Wenzel, Sally E. ; Greenberger, Paul A. / Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. In: Journal of Allergy and Clinical Immunology. 2011 ; Vol. 127, No. 2. pp. 355-360.

RIS

TY - JOUR

T1 - Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

AU - Lotvall, Jan

AU - Akdis, Cezmi A.

AU - Bacharier, Leonard B.

AU - Bjermer, Leif

AU - Casale, Thomas B.

AU - Custovic, Adnan

AU - Lemanske, Robert F.

AU - Wardlaw, Andrew J.

AU - Wenzel, Sally E.

AU - Greenberger, Paul A.

PY - 2011

Y1 - 2011

N2 - It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of asthma and improving treatment and can explain the failure to identify consistent genetic and environmental correlations to asthma. Here we describe a hypothesis whereby the asthma syndrome is divided into distinct disease entities with specific mechanisms, which we have called "asthma endotypes.'' An "endotype'' is proposed to be a subtype of a condition defined by a distinct pathophysiological mechanism. Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested. Using these criteria, we identify several proposed asthma endotypes and propose how these new definitions can be used in clinical study design and drug development to target existing and novel therapies to patients most likely to benefit. This PRACTALL (PRACtical ALLergy) consensus report was produced by experts from the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. (J Allergy Clin Immunol 2011;127:355-60.)

AB - It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of asthma and improving treatment and can explain the failure to identify consistent genetic and environmental correlations to asthma. Here we describe a hypothesis whereby the asthma syndrome is divided into distinct disease entities with specific mechanisms, which we have called "asthma endotypes.'' An "endotype'' is proposed to be a subtype of a condition defined by a distinct pathophysiological mechanism. Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested. Using these criteria, we identify several proposed asthma endotypes and propose how these new definitions can be used in clinical study design and drug development to target existing and novel therapies to patients most likely to benefit. This PRACTALL (PRACtical ALLergy) consensus report was produced by experts from the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. (J Allergy Clin Immunol 2011;127:355-60.)

KW - Asthma

KW - endotype

KW - phenotype

KW - cluster analysis

KW - pathophysiology

KW - epidemiology

U2 - 10.1016/j.jaci.2010.11.037

DO - 10.1016/j.jaci.2010.11.037

M3 - Article

VL - 127

SP - 355

EP - 360

JO - Journal of Allergy and Clinical Immunology

T2 - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 1097-6825

IS - 2

ER -