ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability.

Research output: Contribution to journalArticle

Abstract

Autophagy has emerged as a cell survival mechanism critical for cellular homeostasis, which may play a protective role in atherosclerosis. ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease. However, it is unknown whether ATG16L1 is involved in atherosclerosis. Our aim was to analyze ATG16L1 expression in carotid atherosclerotic plaques in relation to markers of plaque vulnerability.

Details

Authors
  • Joelle Magné
  • Peter Gustafsson
  • Hong Jin
  • Lars Maegdefessel
  • Kjell Hultenby
  • Annika Wernerson
  • Per Eriksson
  • Anders Franco-Cereceda
  • Petri T Kovanen
  • Isabel Goncalves
  • Ewa Ehrenborg
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)1226-1235
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume35
Issue number5
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes