Atrial fibrosis: An obligatory component of arrhythmia mechanisms in atrial fibrillation?

Research output: Contribution to journalReview article

Abstract

Atrial fibrosis is common in atrial fibrillation (AF). Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial fibrosis plays in the mechanisms of AF, however, may differ between patients with structurally normal hearts, such as lone AF, and those with advanced cardiovascular comorbidities.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • Atrial fibrillation, Fibrosis, Remodeling
Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalJournal of Geriatric Cardiology
Volume14
Issue number4
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes