Attenuation of Experimental Atherosclerosis by Interleukin-19.

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Abstract

Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice and identified plausible mechanisms.

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  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)2316-2324
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume33
Issue number10
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes

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