Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients

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Bibtex

@article{1120639dedb446a8ab1dd4bbfffaf346,
title = "Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients",
abstract = "Allogeneic islet transplantation can restore an insulin-independent state in C-peptide-negative type 1 diabetic patients. We recently reported three cases of surviving islet allografts that were implanted in type 1 diabetic patients under maintenance immune suppression for a previous kidney graft. The present study compares islet graft-specific cellular auto- and alloreactivity in peripheral blood from those three recipients and from four patients with failing islet allografts measured over a period of 6 months after portal islet implantation. The three cases that remained C-peptide- positive for >1 year exhibited no signs of alloreactivity, and their autoreactivity to islet autoantigens was only marginally increased. In contrast, rapid failure (<3 weeks) in three other cases was accompanied by increases in precursor frequencies of graft-specific alloreactive T-cells; in one of them, the alloreactivity was preceded by a sharply increased autoreactivity to several islet autoantigens. One recipient had a delayed loss of islet graft function (33 weeks); he did not exhibit signs of graft- specific alloimmunity, but developed a delayed increase in autoreactivity. The parallel between metabolic outcome of human β-cell allografts and cellular auto- and alloreactivity in peripheral blood suggests a causal relationship. The present study therefore demonstrates that T-cell reactivities in peripheral blood can be used to monitor immune mechanisms, which influence survival of β-cell allografts in diabetic patients.",
author = "Roep, {Bart O.} and Inge Stobbe and Gaby Duinkerken and {Van Rood}, {Jon J.} and {\AA}ke Lernmark and Bart Keymeulen and Danny Pipeleers and Claas, {Frans H.J.} and {De Vries}, {Ren{\'e} R.P.}",
year = "1999",
month = jan,
day = "1",
doi = "10.2337/diabetes.48.3.484",
language = "English",
volume = "48",
pages = "484--490",
journal = "Diabetes",
issn = "1939-327X",
publisher = "American Diabetes Association Inc.",
number = "3",

}