Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat
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Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.
|Number of pages||3|
|Publication status||Published - 1984 Jan 1|