Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat

Research output: Contribution to journalArticle

Abstract

Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.

Details

Authors
External organisations
  • Hagedorn Research Institute
Original languageEnglish
Pages (from-to)1348-1350
Number of pages3
JournalScience
Volume224
Issue number4655
Publication statusPublished - 1984 Jan 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes