Autofluorescence insensitive imaging using upconverting nanocrystals in scattering media

Research output: Contribution to journalArticle


Autofluorescence is a nuisance in the field of fluorescence imaging and tomography of exogenous molecular markers in tissue, degrading the quality of the collected data. In this letter, we report autofluorescence insensitive imaging using highly efficient upconverting nanocrystals (NaYF4: Yb3+ /Tm3+) in a tissue phantom illuminated with near- infrared radiation of 85 mW/cm(2). It was found that imaging with such nanocrystals leads to an exceptionally high contrast compared to traditional downconverting fluorophores due to the absence of autofluorescence. Upconverting nanocrystals may be envisaged as important biological markers for tissue imaging purposes. c 2008 American Institute of Physics. [DOI: 10.1063/1.3005588]


  • Can Xu
  • Niclas Svensson
  • Johan Axelsson
  • Pontus Svenmarker
  • Gabriel Somesfalean
  • Guanying Chen
  • Huijuan Liang
  • Haichun Liu
  • Zhiguo Zhang
  • Stefan Andersson-Engels
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Atom and Molecular Physics and Optics
Original languageEnglish
JournalApplied Physics Letters
Issue number17
Publication statusPublished - 2008
Publication categoryResearch

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