Autoimmunity against INS-IGF2 expressed in human pancreatic islets.

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Bibtex

@article{ca46811be1de40ea93467c5666e80e91,
title = "Autoimmunity against INS-IGF2 expressed in human pancreatic islets.",
abstract = "Insulin is a major autoantigen in islet autoimmunity and progression to type 1 diabetes. It has been suggested that the insulin B-chain may be critical to insulin autoimmunity in type 1 diabetes. INS-IGF2 consists of the preproinsulin signal peptide, the insulin B-chain and eight amino acids of the C-peptide in addition to 138 amino acids from the IGF2 gene. We aimed to determine 1) expression of INS-IGF2 in human pancreatic islets and 2) autoantibodies in newly diagnosed type 1 diabetes children and controls. INS-IGF2, expressed primarily in beta cells, showed higher levels of expression in islets from normal compared to donors with either type 2 diabetes (p=0.006) or high HbA1c levels (p<0.001). INS-IGF2 autoantibody levels were increased in newly diagnosed type 1 diabetes patients (n=304) compared to healthy controls (n=355; p<0.001). Displacement with cold insulin and INS-IGF2 revealed that more patients than controls had doubly reactive insulin-INS-IGF2 autoantibodies. These data suggest that INS-IGF2, which contains the preproinsulin signal peptide, the B-chain and eight amino acids of the C-peptide may be an autoantigen in type 1 diabetes. INS-IGF2 and insulin may share autoantibody binding sites, thus complicating the notion that insulin is the primary autoantigen in type 1 diabetes.",
author = "Norio Kanatsuna and Jalal Taneera and {Vaziri Sani}, Fariba and Nils Wierup and Helena Larsson and Ahmed Delli and Hanna Sk{\"a}rstrand and Alexander Balhuizen and Hedvig Bennet and Steiner, {Donald F} and Carina T{\"o}rn and Malin Fex and {\AA}ke Lernmark",
year = "2013",
doi = "10.1074/jbc.M113.478222",
language = "English",
volume = "288",
pages = "29013--29023",
journal = "Journal of Biological Chemistry",
issn = "1083-351X",
publisher = "ASBMB",
number = "40",

}