Automated Operant Assessments of Huntington's Disease Mouse Models

Research output: Contribution to journalArticle

Abstract

Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.

Details

Authors
Organisations
External organisations
  • Cardiff University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • 9-Hole box, Behavior, Cognition, Huntington’s disease, Knockin, Mouse model, Operant, Skinner box, Touch screen, Transgenic
Original languageEnglish
Pages (from-to)143-162
Number of pages20
JournalMethods in molecular biology (Clifton, N.J.)
Volume1780
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes