Axonal growth in mesothelial chambers. The role of the distal nerve segment

Research output: Contribution to journalArticle

Abstract

An experimental model is presented for studying nerve regeneration over gaps of various lengths between the both ends of a severed nerve. After transferring left and right sciatic nerves of rat to the back, the gap between the two nerve ends could be bridged by a preformed, tube-shaped mesothelial chamber of a desired length. When the gap length was 10 mm or less, a well developed nerve structure was generated in the chamber between the nerve ends, and axons from the left sciatic nerve reinnervated muscles in the right limb via the right sciatic nerve. When the gap length was extended to 15 mm or more no such regeneration occurred. When no distal nerve end was introduced into the chamber, there was a limited growth into this chamber over only 5-6 mm. This "limited growth phenomenon" is discussed with respect to a lack of "trophic" or cellular support from a distal nerve segment. It is also proposed that the termination of growth, seen under these circumstances, may suggest a new principle for avoiding the development of neuromas after nerve transections.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
  • Orthopedics

Keywords

  • Animals, Axons, Nerve Regeneration, Neuroma, Rats, Rats, Inbred Strains, Sciatic Nerve, Surgical Procedures, Operative, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
Original languageEnglish
Pages (from-to)119-25
JournalScandinavian Journal of Plastic and Reconstructive Surgery
Volume17
Issue number2
Publication statusPublished - 1983
Publication categoryResearch
Peer-reviewedYes