B cells.

Research output: Contribution to journalReview article

Abstract

B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other processes including somatic hypermutation, gene conversion and class switching. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two Ig heavy chains, two Ig light chains and two heterodimers of Igalpha and Igbeta. To eliminate foreign antigens, B cells cooperate with other cells of the immune system including macrophages, dendritic cells and T cells. B cell development is a tightly controlled process in which over 75% of the developing cells become apoptotic because of inappropriate immunoglobulin gene rearrangements or recognition of self antigens by Igs. Hence, the majority of B cell-associated disorders are caused by the incorrect function of genes/proteins involved in B cell development.

Details

Authors
External organisations
  • University of Tampere
  • Tampere University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics

Keywords

  • B-Cell: genetics, Antigen, Receptors, Immunoglobulins: deficiency, Immunoglobulin alpha-Chains: genetics, Immunoglobulin Light Chains: genetics, Immunoglobulin Heavy Chains: genetics, Immunoglobulin G: metabolism, Immunoglobulin G: genetics, B-Lymphocytes: immunology, B-Lymphocytes: metabolism, B-Cell: metabolism, T-Lymphocytes: immunology, VDJ Recombinases: genetics
Original languageEnglish
Pages (from-to)518-523
JournalInternational Journal of Biochemistry & Cell Biology
Volume37
Issue number3
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes